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Part VII – Atherosclerotic Cardiovascular Diasease

Chapter 52 – Coronary Blood Flow and Myocardial Ischemia

John M. CantyJr.

  CONTROL OF CORONARY BLOOD FLOW, 1049
  Determinants of Myocardial Oxygen Consumption, 1049
  Determinants of Coronary Vascular Resistance, 1052

  PHYSIOLOGIC ASSESSMENT OF CORONARY ARTERY STENOSES, 1058
  Stenosis Pressure-Flow Relationship, 1058
  Interrelationship Among Distal Coronary Pressure, Flow, and Stenosis Severity, 1059
  Concept of Maximal Perfusion and Coronary Reserve, 1059
  Pathophysiologic States Affecting Microcirculatory Coronary Flow Reserve, 1063

  CORONARY COLLATERAL CIRCULATION, 1064
  Arteriogenesis and Angiogenesis, 1065
  Regulation of Collateral Resistance, 1065

  METABOLIC AND FUNCTIONAL CONSEQUENCES OF ISCHEMIA, 1066
  Irreversible Injury and Myocyte Death, 1066
  Reversible Ischemia and Perfusion-Contraction Matching, 1066
  Functional Consequences of Reversible Ischemia, 1067

  FUTURE PERSPECTIVES, 1072
  REFERENCES, 1074

The coronary circulation is unique in that it is responsible for …