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Part VI – Preventive Cardiology

Chapter 43 – The Vascular Biology of Atherosclerosis

Peter Libby

  STRUCTURE OF THE NORMAL ARTERY, 897
  Cell Types Composing the Normal Artery, 897

  ATHEROSCLEROSIS INITIATION, 900
  Extracellular Lipid Accumulation, 900
  Leukocyte Recruitment, 900
  Focality of Lesion Formation, 903
  Intracellular Lipid Accumulation: Foam Cell Formation, 904

  EVOLUTION OF ATHEROMA, 904
  Innate and Adaptive Immunity: Mechanisms of Inflammation in Atherogenesis, 904
  Smooth Muscle Cell Migration and Proliferation, 905
  Smooth Muscle Cell Death During Atherogenesis, 905
  Arterial Extracellular Matrix, 906
  Angiogenesis in Plaques, 906
  Plaque Mineralization, 906

  COMPLICATION OF ATHEROSCLEROSIS, 906
  Arterial Stenoses and Their Clinical Implications, 906
  Thrombosis and Atheroma Complication, 907
  Plaque Rupture and Thrombosis, 907
  Thrombosis due to Superficial Erosion of Plaques, 908
  Diffuse and Systemic Nature of Plaque Vulnerability and Inflammation in Atherogenesis, 909

  SPECIAL CASES OF ARTERIOSCLEROSIS, 910
  Restenosis …