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Chapter 71 – Chagas’ Disease

José A.F. Ramires,
Andrei C. Sposito,
Edécio Cunha Neto,
Maria de Lourdes Higuchi

  PATHOLOGIC FINDINGS, 1611
  PATHOPHYSIOLOGY, 1611
  CLINICAL MANIFESTATIONS, 1614
  Acute Phase, 1614
  Indeterminate and Chronic Phases, 1615

  LABORATORY EVALUATION, 1615
  Diagnosis, 1615
  Echocardiography, 1615
  Imaging Studies, 1615

  MANAGEMENT, 1615
  Antitrypanosomal Drug Treatment, 1615
  Concomitant Treatment, 1616

  CHAGAS’ DISEASE IN THE UNITED STATES, 1616
  REFERENCES, 1616

Chagas’ disease, or American trypanosomiasis, is an infection caused by the protozoan Trypanosoma cruzi (T. cruzi), originally transmitted by hematophagous triatomine insects.[1,2] Triatominae infected by T. cruziinhabit 18 countries in North and South America, ranging from the southern United States to southern Argentina, and the prevalence of the disease relates to the proximity between infected triatomines and humans. The infection can also result from maternal-fetal transmission, from food contaminated with feces or urine from infected …