Patients with lipoprotein disorders should undergo comprehensive evaluation and management in the context of a global risk reduction program. Most patients with dyslipoproteinemias lack symptoms, except for those with severe hypertriglyceridemia who can present with acute pancreatitis and those with familial lipoprotein disorders who have cutaneous manifestations (e.g., xanthomas, xanthelasmas). In the evaluation of patients with dyslipidemia, secondary causes should be sought and treated. The clinical evaluation should include a thorough history, including a complete family history, which may reveal clues about the genetic cause and also the genetic susceptibility to CVD. The physician should seek and address other risk factors (e.g., cigarette smoking, obesity, diabetes, hypertension, lack of exercise) and institute measures to improve lifestyle (e.g., diet, physical activity, alcohol intake). Such interventions should make use of …