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Chapter 23 – Molecular Imaging in Cardiovascular Disease

Peter Libby,
Farouc A. Jaffer,
Ralph Weissleder

  PRINCIPLES OF MOLECULAR IMAGING, 448
  Imaging Strategies, 448

  BIOLOGIC PROCESSES AMENABLE TO MOLECULAR TARGETING FOR IMAGING, 449
  Cell Trafficking: Leukocytes and Stem Cells, 449
  Phagocytosis, 452
  Myocardial Injury, 453
  Cell Surface Structures: Receptors, Integrins, Adhesion Molecules, 453
  Angiogenesis, 453
  Apoptosis, 455
  Proteolytic Enzymes, 455
  Glucose Metabolism, 455
  Imaging of Transcriptional Activity, 456
  Neurotransmitter Labeling of Autonomic Activity, 456

  USES FOR MOLECULAR IMAGING, 456
  THE FUTURE OF MOLECULAR IMAGING OF THE CARDIOVASCULAR SYSTEM, 457
  REFERENCES, 457

Recently, unraveling of the molecular and cellular bases of cardiovascular disease has accelerated. We now possess sufficient knowledge to identify numerous cellular behaviors, as well as molecular signaling and regulatory pathways that participate in the pathogenesis of many cardiovascular diseases. These advances in our understanding of …