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CHAPTER 42 – Lipoprotein Disorders and Cardiovascular Disease

Jacques Genest,
Peter Libby

  Introduction, 1071
  Lipoprotein Transport System, 1071
  Biochemistry of Lipids, 1071
  Lipoproteins, Apolipoproteins, Receptors, and Processing Enzymes, 1072
  Lipoprotein Metabolism and Transport, 1073

  Lipoprotein Disorders, 1077
  Definitions, 1077
  Genetic Lipoprotein Disorders, 1078
  Low-Density Lipoproteins (Type II Hyperlipidemia), 1078
  Triglyceride-Rich Lipoproteins, 1079
  High-Density Lipoproteins, 1081

  Secondary Causes of Hyperlipidemia, 1081

  Drugs That Affect Lipid Metabolism, 1082
  Bile Acid–Binding Resins, 1082
  HMG-CoA Reductase Inhibitors (Statins), 1083
  Cholesterol Absorption Inhibitors, 1083
  Fibric Acid Derivatives (Fibrates), 1083
  Nicotinic Acid (Niacin), 1083
  CETP Inhibitors, 1084
  Fish Oils, 1084
  Phytosterols, 1084
  Other Medications, 1084
  Monitoring of Lipid Therapy, 1084

  Clinical Trials of Drugs Affecting Lipid Metabolism, 1084
  Treating High-Risk (Primary Prevention) Patients, 1084
  Hypertensive Patients, 1086
  Diabetic …