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MOSBY ELSEVIER

An imprint of Elsevier Limited

© 2008, Elsevier Limited. All rights reserved.

© William Coleman III retains copyright of his original figures in  chapter 156.

© Gabriele Richard retains copyright for her original figures in  chapter 56.

©  Chapters 4 and  84 are US Government works in the public domain and not subject to copyright.

The right of Jean L Bolognia, Joseph L Jorizzo, Ronald P Rapini, Jeffrey P Callen, Thomas D Horn, Anthony J Mancini, Stuart J Salasche, Julie V Schaffer, Thomas Schwarz, Georg Stingl and Mary Seabury Stone to be identified as authors of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988.

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier's Rights Department: phone: (+1) 215 239 3804 (US) or (+44) 1865 843830 (UK); fax: (+44) 1865 853333; e-mail: healthpermissions@elsevier.com. You may also complete your request on-line via the Elsevier website at http://www.elsevier.com/permissions.

First published 2003

Reprinted 2003 (twice)

Reprinted 2004

Second edition 2008

ISBN: 9781416029991

ISBN (E-dition): 9781416032694

British Library Cataloguing in Publication Data

A catalogue record for this book is available from the British Library