Synonyms

	▪	Exfoliative dermatitis ▪ Exfoliative erythroderma
	▪	Red man syndrome

	▪	Erythroderma is defined clinically as generalized redness and scaling of the skin
	▪	Systemic manifestations include peripheral edema, tachycardia, loss of fluid and proteins, and disturbances in thermoregulation
	▪	Erythroderma has multiple etiologies; the most common causes are psoriasis, atopic dermatitis, cutaneous T-cell lymphoma (CTCL) and drug reactions
	▪	Establishing the correct diagnosis requires consideration of initial sites of involvement, additional clinical findings, histologic and molecular features, and associated systemic abnormalities, as well as a complete medical history
	▪	Despite an intensive evaluation, the cause remains unknown (idiopathic) in 25-30% of patients; some of these patients eventually develop CTCL
	▪	Treatment strategies should address the dermatologic disease as well as the underlying etiology and the systemic complications of the …