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Chapter 88 – Rheumatic Fever

B. Soma Raju,
Zoltan G. Turi

  EPIDEMIOLOGY, 1868
  PATHOBIOLOGY, 1868
  PATHOLOGY, 1869
  DIAGNOSIS, 1869
  Jones Criteria, 1869
  Carditis, 1870
  Arthritis, 1871
  Chorea, 1872
  Cutaneous Manifestations, 1872
  Laboratory Findings, 1872

  TREATMENT, 1872
  Prevention Strategies, 1873
  Therapeutic Modalities, 1873

  FUTURE DIRECTIONS, 1874
  REFERENCES, 1874

Rheumatic fever (RF) is an autoimmune disorder that remains incompletely characterized with regard to its basic elements—cause, pathophysiology, diagnosis, and treatment—despite evidence of its existence dating to at least the 1600s. The classic understanding that the disease is a post–suppurative streptococcal pharyngitis cascade, leading variably to arthritis, chorea, dermal manifestations, and, most important, carditis, has largely withstood challenge. Immunologic studies have confirmed the presence of epitopes on the bacterial surface that mimic cardiac myosin as well as antigens found in valve, skin, joint, and brain tissue that account for the …