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Lipoprotein Disorders

Definitions

Time and new information have stimulated changes to the classification of lipoprotein disorders. The original classification of lipoprotein disorders by Donald Fredrickson and colleagues in 1967 used the measurement of total plasma cholesterol and triglycerides and lipoprotein patterns analyzed by electrophoresis. This classification recognized elevations of chylomicrons (type I), VLDL or prebeta lipoproteins (type IV), broad beta disease (or type III hyperlipoproteinemia), beta lipoproteins (LDL; type II), and elevations of both chylomicrons and VLDL (type V). In addition, the combined elevation of prebeta (VLDL) and beta (LDL) lipoproteins was denoted type IIb hyperlipoproteinemia. Although providing a useful conceptual framework, this classification has some drawbacks; it does not include HDL cholesterol and it does not differentiate severe monogenic lipoprotein disorders from the more common polygenic disorders. Subsequently, the World Health …