/Neuroendocrinology and Pituitary Disease/ - Endocrinology: Expert Consult

PART II – Neuroendocrinology and Pituitary Disease

Chapter 8 – Development of the Pituitary

Dorota Skowronska-Krawczyk,
Michael G. Rosenfeld

Anatomy and Histology

Pituitary Development

		Origin
		Ontogeny
		Cell Lineage Determination

Transcription Factors and Pituitary Development

		Pit1 Gene
		Prop1 Gene
		Hesx1 Gene
		Lhx3 and Lhx4 Genes
		Tbx19 Gene
		Pitx1 and Pitx2 Genes
		Other Transcription Factors

Signaling Pathways in Pituitary Development

		Sonic Hedgehogs
		Fibroblast Growth Factors
		Transforming Growth Factors and BMPs
		Notchs
		Wnts
		Interactions Between Different Morphogenic Factors
		Other Potential Morphogenic Factors

Pituitary and Epigenics

		Pit1 Locus—Multiple Enhancers Coordinate Expression of the Gene
		Growth Hormone Locus—LCR, Boundary, and Histone Code

Adult Pituitary Stem Cells

Summary

Advancement in genetic and molecular biology techniques has significantly increased our understanding of mechanisms underlying the development of the pituitary gland. The pituitary gland serves as an intermediary between the brain and the peripheral …