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PART II – Neuroendocrinology and Pituitary Disease

Chapter 8 – Development of the Pituitary

Dorota Skowronska-Krawczyk,
Michael G. Rosenfeld

  Anatomy and Histology
  Pituitary Development
  Origin
  Ontogeny
  Cell Lineage Determination

  Transcription Factors and Pituitary Development
  Pit1 Gene
  Prop1 Gene
  Hesx1 Gene
  Lhx3 and Lhx4 Genes
  Tbx19 Gene
  Pitx1 and Pitx2 Genes
  Other Transcription Factors

  Signaling Pathways in Pituitary Development
  Sonic Hedgehogs
  Fibroblast Growth Factors
  Transforming Growth Factors and BMPs
  Notchs
  Wnts
  Interactions Between Different Morphogenic Factors
  Other Potential Morphogenic Factors

  Pituitary and Epigenics
  Pit1 Locus—Multiple Enhancers Coordinate Expression of the Gene
  Growth Hormone Locus—LCR, Boundary, and Histone Code

  Adult Pituitary Stem Cells
  Summary

Advancement in genetic and molecular biology techniques has significantly increased our understanding of mechanisms underlying the development of the pituitary gland. The pituitary gland serves as an intermediary between the brain and the peripheral …