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Chapter 17 – TSH-Producing Adenomas

Paolo Beck-Peccoz,
Luca Persani

   Epidemiology
   Pathology and Etiopathogenesis
   Clinical Features
   Biochemical Findings
   TSH and Thyroid Hormone Levels
   Glycoprotein Hormone α Subunit
   Parameters Evaluating Peripheral Thyroid Hormone Action

   Dynamic Testing
   Imaging Studies and Localization
   Differential Diagnosis
   Treatment and Outcome
   Pituitary Surgery and Radiation Therapy
   Medical Treatment

   Criteria of Cure and Follow-Up
   Conclusions

Pituitary thyrotropin-producing adenomas (TSH-omas) are rare tumors that cause hyperthyroidism by chronically stimulating an intrinsically normal thyroid gland.[1-4] The first case of hyperthyroidism related to TSH-oma (central hyperthyroidism) was reported in 1960 when serum TSH levels were measured with a bioassay.[5] In 1970, Hamilton and coworkers[6]documented the first case of TSH-oma that was indisputably proved by radioimmunoassay techniques. Since then, about 350 patients have been reported in the literature. Although early reports describe these tumors …