Paolo Beck-Peccoz,
Luca Persani
Chapter 17 – TSH-Producing Adenomas
Pituitary thyrotropin-producing adenomas (TSH-omas) are rare tumors that cause hyperthyroidism by chronically stimulating an intrinsically normal thyroid gland.[1-4] The first case of hyperthyroidism related to TSH-oma (central hyperthyroidism) was reported in 1960 when serum TSH levels were measured with a bioassay.[5] In 1970, Hamilton and coworkers[6]documented the first case of TSH-oma that was indisputably proved by radioimmunoassay techniques. Since then, about 350 patients have been reported in the literature. Although early reports describe these tumors …