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Chapter 15 – Cushing's Syndrome

Damian G. Morris,
Ashley Grossman,
Lynnette K. Nieman

  
  Definition
  Etiology and Pathophysiology
  Pseudo-Cushing's States
  Epidemiology
  Clinical Features
  Pathology
  Clinical Spectrum
  Diagnosis and Differential Diagnosis
  Establishing the Diagnosis of Cushing's Syndrome
  Differential Diagnosis of Cushing's Syndrome
  Treatment
  Surgery
  Radiotherapy
  Medical Treatment

  Special Clinical Scenarios
  Cyclic Cushing's Syndrome
  Iatrogenic and Factitious Cushing's Syndrome
  Chronic Renal Failure
  Pediatric Cushing's Syndrome
  Cushing's Syndrome in Pregnancy

  Prognosis

Harvey Cushing[1,2] was the first to codify the symptom complex of obesity, diabetes, hirsutism, and adrenal hyperplasia, and to postulate that the basophilic adenomas found at autopsy in six of eight patients caused the disease that now bears his name. Shortly thereafter, Walters and colleagues[3]identified the etiologic contribution of adrenal tumors and the therapeutic role of adrenalectomy. Over the ensuing century, our understanding of the …