Hypopituitarism refers to the deficiency of one or more pituitary hormones. It is seen commonly in endocrine practice and, it is important to note, is associated with increased morbidity and mortality. Clinical manifestations are influenced by the cause, severity, and rate of onset of pituitary hormone deficiency.

Adult patients with hypopituitarism receive substitutive hormone treatment for secondary glucocorticoid, sex steroid, and thyroid hormone deficiency. Until recently, growth hormone (GH) deficiency was not regarded as clinically important, as it was assumed that GH had no physiologic relevance after cessation …