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DIAGNOSIS

In a known endemic area of Chagas' disease, Romana's sign is suggestive of acute infection, although there are other potential causes of unilateral conjunctivitis such as insect bite or injury. Many of the systemic signs of early Chagas' disease are not specific and could be confused with other febrile illnesses. In chronic disease, particular ECG abnormalities (e.g. RBBB) are highly indicative if associated with positive serological findings. Hirschsprung's megacolon can be distinguished from chagasic megacolon because the former is rare in adults; if necessary, radiography or electromanometry can be used for differential diagnosis.[2]For immigrants or travellers returning from Latin America who have symptoms that might be attributable to Chagas' disease, it is essential to investigate thoroughly for the presence of a supporting history, such as exposure to triatomine bugs or blood transfusion. Rarely, infection in endemic areas might be acquired by food contaminated with …