//DIAGNOSIS 4-u1.0-B978-1-4160-4470-3..50079-3--cesec11 4-u1.0-B978-1-4160-4470-3..50079-3..DOCPDF Chapter 75 4-u1.0-B978-1-4160-4470-3..50079-3 4-u1.0-B978-1-4160-4470-3..50079-3--cesec10 Immunodiagnostic methods 4-u1.0-B978-1-4160-4470-3..50079-3--cesec12 Immunodiagnostic methods Human African Trypanosomiasis Section 10 4-u1.0-B978-1-4160-4470-3..50079-3--cesec11 Protozoan Infections hubsection 4 section Protozoan Infections Section 10 4-u1.0-B978-1-4160-4470-3..50079-3 4-u1.0-B978-1-4160-4470-3..50079-3--cesec10 Human African Trypanosomiasis 4-u1.0-B978-1-4160-4470-3..X5001-0--section10 Human African Trypanosomiasis text/html; charset=ISO-8859-1 DIAGNOSIS Chapter 75 chapter bookContent 4-u1.0-B978-1-4160-4470-3..X5001-0--section10 DIAGNOSIS 4-u1.0-B978-1-4160-4470-3..50079-3 4-u1.0-B978-1-4160-4470-3..X5001-0--section10 4-u1.0-B978-1-4160-4470-3..50079-3 4-u1.0-B978-1-4160-4470-3..50079-3--cesec9 6 section 4-u1.0-B978-1-4160-4470-3..50079-3--cesec11 4-u1.0-B978-1-4160-4470-3..50079-3--cesec10 Chapter 75 Manson's Tropical Diseases 978-1-4160-4470-3 Cook 22nd
DIAGNOSISThe diagnosis of T.b. gambiense human African trypanosomiasis (HAT usually follows a three-step pathway: screening, diagnostic confirmation, and staging. Suspected cases detected by serological methods (usually the card agglutination test for trypanosomiasis; CATT) undergo parasitological diagnosis by investigation of the blood and/or lymph (Figure 75.8) and in case of a positive result, examination of the CSF follows for stage determination.[47] T.b. rhodesiense is usually directly detected in the blood.
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Immunodiagnostic methodsField diagnosis of infections with Trypanosoma brucei gambiense relies on the initial screening with the card agglutination trypanosomiasis test (CATT/T.b. gambiense) in most endemical areas. The test is a cheap, quick, and practical serological test that has been widely used since it was developed in 1978.[48]The basis is a reagent composed of stained freeze-dried trypanosomes of selected variable antigen types (VATs), which can be obtained from the …
