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Chapter 78 – Proliferative vitreoretinopathy

Clyde Guidry

Clinical background

Proliferative vitreoretinopathy (PVR) is defined as the “growth of membranes on both surfaces of the detached retina and on the posterior surface of the detached vitreous gel.” The name was introduced in 1983 by the Retina Society Terminology Committee[1]as part of a classification scheme for a group of intraocular complications previously known by more descriptive terms, including “massive vitreous retraction,” “massive preretinal retraction,” and “massive periretinal proliferation.” PVR is not a distinct disease per se, but is instead a complication common to a variety of clinical disorders. It is most prevalent as a clinical complication of surgical procedures to correct rhegmatogenous retinal detachments, which are detachments that follow formation of a retinal tear or hole. Tractional forces generated within the scar tissue-like PVR membranes can be transmitted to the retina and cause complete retinal detachment, …