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chapter 16 – Membrane stabilizers

Robert W. Hurley, MD, PhD,
Honorio T. Benzon, MD,
Emily Davoodi, MD, PharmD

The treatment of neuropathic pain presents a distinct challenge for health-care practitioners. A wide range of conditions resulting in chronic neuropathic pain include, but are not limited to, diabetic polyneuropathy, postherpetic neuralgia, central neuropathic pain, traumatic/surgical nerve injury, incomplete spinal cord injury, trigeminal neuralgia, multiple sclerosis, radiculopathy, complex regional pain syndrome (CRPS), and HIV-associated peripheral neuropathy. Defined as pain initiated or caused by a primary lesion or dysfunction in the nervous system, neuropathic pain is often described as burning, lancinating, or tingling in nature.

Neuropathic pain is the unfortunate consequence of detrimental changes that occur after tissue injury.[1]Pathologic changes after injury result in plasticity or alterations in the way peripheral nerve fibers respond to and deliver input to the central nervous …