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137 – Infections in the Immunocompromised Patient

Yoshiro Hayashi,
David L. Paterson

Many immunocompromised patients are managed in intensive care units (ICUs) every year, with infection being a leading cause of ICU admission. Common examples of such infections include community-acquired pneumonia, bacteremia, and central nervous system (CNS) infections. The incidence of infections acquired by immunocompromised patients during ICU admissions is also significant.[1] Mortality for certain infections in immunocompromised patients exceeds 50%.[2] Early diagnosis, initiation of appropriate antimicrobial and supportive therapy, and reduction in immunosuppression where possible can improve outcome significantly.

   Commonly Encountered Immunocompromising Conditions

Immunocompromisecan be broadly defined as a state in which the response of the host to a foreign antigen is subnormal. Immunocompromise could be congenital (primary) or acquired. Congenital immunodeficiencies are now much less common than acquired …