Full-size Left-side Hidden
Granulomatous Sialadenitis

Granulomatous sialadenitis can be caused by infection (fungi, mycobacteria, toxoplasmosis, and cat scratch disease), sarcoidosis, cyst rupture, and rarely neoplasia (Hodgkin lymphoma, T-cell lymphoma, or metastatic carcinoma).[60–62] Aspirates are characterized by a variable background of granular, necrotic cell debris and inflammation, together with aggregates of epithelioid histiocytes, frequently with multinucleated forms. Epithelioid histiocytes have abundant eosinophilic cytoplasm and cytologically bland, elongated, folded nuclei with indistinct nucleoli. Asteroid bodies, Schaumann bodies, and calcium oxalate crystals can be present in sarcoidosis, but these findings are not specific, and an infectious etiology must be excluded by special stains or microbiologic cultures.[63]