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Neutrophils are a major component of the inflammatory cell infiltrate in the dermis in early lesions of dermatitis herpetiformis and in linear IgA bullous dermatosis, mucous membrane pemphigoid, ocular cicatricial (mucous membrane) pemphigoid, and localized cicatricial pemphigoid. Bullae are an uncommon manifestation of urticaria, acute vasculitis, lupus erythematosus, erysipelas, and Sweet's syndrome. Intraepidermal neutrophilic spongiosis and subepidermal vesicles with neutrophils may be seen in rheumatoid neutrophilic dermatosis.[1813] Neutrophils are abundant in some inflammatory forms of epidermolysis bullosa acquisita and in the recently described entities of deep lamina lucida (anti-p105) pemphigoid and anti-p200 pemphigoid. A ‘superficial neutrophilic dermolysis with subepidermal bulla formation’ has been reported in a patient with hepatobiliary disease.[1814]


Dermatitis herpetiformis is a rare, chronic, subepidermal …