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DISORDERED PROLIFERATIVE TO BENIGN ENDOMETRIAL HYPERPLASIA SEQUENCE

DEFINITION

Benign endometrial hyperplasia is a functional class of diffuse estrogen-induced lesions characterized by irregular remodeling of glands, and variably accompanied by vascular thrombi, stromal breakdown, and randomly scattered cytologic changes. It is preceded by disordered proliferative endometrium, an intermediate step between normal proliferative and benign hyperplastic endometrium. The combination and severity of features progressively increases with duration of exposure and may be retained even if the estrogen level declines or is quenched by addition of progestins (benign hyperplasia with superimposed progestin effect). They are best construed as a sequence of changes, whereby the appearance at any single timepoint is uniquely dependent on the preceding combination and duration of hormonal exposures. Benign hyperplasia of the endometrium has also been referred to as disordered proliferative, proliferative …