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Prognosis and Treatment

Local, complete excision is adequate treatment, and no malignant behavior is documented.

CUTANEOUS MYXOMA—FACT SHEET
Definition

  ▸▸    Benign myxoid mesenchymal tumor of the skin and subcutis

Incidence and Location

  ▸▸    Rare
  ▸▸    Sporadic cutaneous myxoma: trunk, legs, head and neck
  ▸▸    Carney syndrome–associated myxomas: eyelids and ear, may be multiple

Morbidity and Mortality

  ▸▸    None

Sex, Race, and Age Distribution

  ▸▸    Most often occur in middle-aged men

Clinical Features

  ▸▸    Polypoid or papular skin lesion

Prognosis and Treatment

  ▸▸    May recur locally
  ▸▸    Complete excision

CUTANEOUS MYXOMA—PATHOLOGIC FEATURES
Gross Findings

  ▸▸    Poorly circumscribed, gelatinous, small

Microscopic Findings

  ▸▸    Vaguely lobular
  ▸▸    Much more vascular than other myxomas; may show well-developed arborizing vasculature
  ▸▸    Bland spindled cells
  ▸▸    Abundant myxoid matrix
  ▸▸    Stromal neutrophils and entrapped adnexal units in some

Immunohistochemical Findings

  ▸▸    Typically express only vimentin

Differential Diagnosis

  ▸▸    Cutaneous mucinosis, digital …